Remdesivir Risk Versus Benefits Assessment

Drug Trials & Reports

Several reports undertaken into the adverse events of remdesivir conclude remdesivir causes a long list of adverse effects, the most critical being a 53% mortality rate. Remdesivir also causes kidney and liver injury.

In contrast, following a drug trial in February 2020, the only reported benefit remdesivir offered was a possible reduction in hospitalisation by 4 days. That report stated deaths occurred from remdesivir during the drug trial, however the mortality statistics were ignored, and mortality information kept from the world.

In consideration of risk versus benefit, it is incomprehensible any doctor would elect to inject a toxic poison that leads to 53% death, and/or kidney and liver injury where the only benefit may be a reduction of 4 days in hospital.

A poison is a substance that can cause death or injury. Remdesivir causes injury and death. Remdesivir is a poison.

Frank died with almost all of the published adverse effects of remdesivir, including death, multi organ failure, kidney failure, acute kidney injury, deep vein thrombosis, bruising and swelling to his face, body, lips and eyes.

 

Benefits of Remdesivir

BENEFIT: 4 days less in hospital

Following a drug trial for covid in February 2020, the only reported benefit of remdesivir is that it may reduce hospitalisation from 15 days to 11 days.

Mortality that resulted in the drug trail was ignored. As such, an entirely false representation of remdesivir was issued to the world.

In October 2020 The World Health Organisation (WHO) said remdesivir had “little or no effect in preventing death from COVID-19 or reducing time in hospital.”

 

Adverse Effects of Remdesivir

ADVERSE EFFECTS: Death, multi-organ failure, liver failure, kidney injury, +++++

The US National Institutes of Health (NIH) National Library of Medicine provides several remdesivir drug trial reports on its website. Links to the referenced reports are provided below.

On 22 May 2020 Drugs In Context (DIC) published a report titledThe journey of remdesivir: from Ebola to COVID-19”. The report was completed on 14 April 2020. The report outlines results of four drugs trialled to treat ebola. Remdesivir resulted in the highest death rate of the four drugs, with a death rate of 53.1%.

Page 4 the report states, “At day 28, mortality rates were: remdesivir (53.1%)”

NIAID was involved in, and provided funding for, the ebola drug trials, and as such was aware of the 53% dealth rate of remdesivir.

On 22 July 2020 Biomed Pharmacother published a report titled, Safety profile of the antiviral drug remdesivir: An update”. The report provides a list of adverse events of remdesivir and the number of events (shown as a percentage below):

  1. increased hepatic enzyme 25% (hepatitis or liver disease);

  2. respiratory failure 4%;

  3. pneumothorax 4% (collapsed lung - air leaks into the space between lungs and chest wall];

  4. hypotension: 8% (high blood pressure);

  5. atrial fibrillation 6% (irregular heart rate - heart’s upper chambers beat out of coordination with the lower chamber);

  6. cardiac arrest 1%;

  7. renal impairment 8% [kidneys lose ability to remove waste);

  8. acute kidney injury 6%;

  9. hematuria 4% (blood in urine); and

  10. constipation, nausea, diarrhea, and gastroparesis.

The report also states, “Other adverse effects. Transient rise in serum amylase was reported in an Ebola-infected patient treated with remdesivir. Grein et al.’s study mentioned rash, multiple-organ-dysfunction syndrome, deep-vein thrombosis, delirium, septic shock, pyrexia as adverse events occurred in remdesivir recipients. Adverse events related to hematologic, circulatory, endocrine and other systems were also detected in the remdesivir group in the RCT in China.”

On 24 October 2020 Cureus published a report titled “Cardiac Adverse Events with Remdesivir in COVID 19 Infection. The report states Adverse effects are common with remdesivir, but few studies exist that focus on remdesivir and its effects on the cardiovascular system. Out of a study of 53 patients receiving remdesivir, 32 patients (60%) experienced adverse events during follow-up. These adverse events were increased hepatic enzymes, diarrhea, rash, renal impairment, and hypotension. Adverse events were more common for those on mechanical ventilation compared to those that were not.”

Queensland Health issued a document titled “Patient Information Remdesivir (Veklury)” which states remdesivir can cause swelling of the face, lips, tongue and other parts ofd the body, and severe skin rash including, itching and hives and nausea and vomiting.

WHO recommends against use of remdesivir to treat covid-19

November 2020 the World Health Organisation
issued conditional recommendation AGAINST USE OF REMDESIVIR

WHO’s position against on use of remdesivir has not changed

WHO issued a “conditional recommendation” against the use of remdesivir to treat covid which means according to its statement, “the evidence around the benefits and risks of an intervention are less certain.”

WHO also stated there was no evidence remdesivir improved survival and other outcomes in patients with the use of remdesivir in hospitalized patients, regardless of disease severity.

WHO arrived at its conditional recommendation based on a drug trial, Repurposed Antiviral Drugs for Covid-19 - Interim WHO Solidarity Trial Results in which four drugs were analysed for the treatment of covid-19, including remdesivir, hydroxychloroquine, lopinavir, and interferon beta-1a. The trial commenced on 22 March 2020 and ended on 4 October 2020. The first report was published on 2 December 2020.

The report concluded, “These remdesivir, hydroxychloroquine, lopinavir, and interferon regimens had little or no effect on hospitalized patients with Covid-19.” Subseqently, WHO made its recommendation against use of remdesivir. In a statement on its website WHO said, “The evidence suggested no important effect on mortality, need for mechanical ventilation, time to clinical improvement, and other patient-important outcomes.” WHO’s recommendation has not changed since its initial recommendation.

WHO’s statement also says, “The guideline development group recognized that more research is needed, especially to provide higher certainty of evidence for specific groups of patients. They supported continued enrollment in trials evaluating remdesivir.” Several other drug trials were undertaken during 2020 throughout the world, however every report concluded that no antiviral agents have been shown to be efficacious.

Noteworthy, the WHO 2020 drug trial reported a death rate of 12.5% for patients in the remdesivir group. Adverse events were not addressed.

In 2018-19 WHO was involved in the ebola drug trials which published its results in Demcember 2019. That report states remdesivir resulted a death rate of 53.1%.

As such in December 2019 the World Health Organisation was aware remdesivir was a highly toxic drug that had a death rate, and determined remdesivir was not suitable to treat ebola. Then in 2020, WHO determined remdesivir had “no benefits” to treat covid, yet refused to inform of remdesivir’s catastrophic death rate or adverse events.

Despite all reports that state remdesivir has NO BENEFITS, in mid 2020 remdesivir became the global hospital protocol to treat covid-19, including Australia.

Main stream media reported on WHO’s recommendations in October and November 2020, prior the report being officially published. Links are below.

Medical Journals

WHO Rejects Remdesivir as a Covid Treatment

Becker’s Hospital Review re-iterated WHO’s rejection of remdesivir to treat covid, referencing a medical journal published on 11 February 2021, titled A Large, Simple Trial Leading to Complex Questions. Links to both are provided below.

In summary, the medical journals says, “The case for the continued use of remdesivir is more nuanced. In this large trial, no substantial mortality benefit was noted with remdesivir across a variety of health care settings.”